Impact of an Antibacterial Toothpaste as an Adjunct to Scaling and Root Planing on Gingivitis and the Relative Abundance of Periodontal Pathogens: A Three-Month Randomized Controlled Trial
배광학, 김혜성, 김영연, 조수정, 조현재,
소속 상세정보
배광학 ( Bae Kwang-Hak ) - Apple Tree Dental Hospital Apple Tree Institute of Biomedical Science
김혜성 ( Kim Hye-Sung ) - Apple Tree Dental Hospital Apple Tree Institute of Biomedical Science
김영연 ( Kim Young-Youn ) - Apple Tree Dental Hospital Apple Tree Institute of Biomedical Science
조수정 ( Jo Su-Jung ) - Apple Tree Dental Hospital Apple Tree Institute of Biomedical Science
조현재 ( Cho Hyun-Jae ) - Seoul National University School of Dentistry Department of Preventive Dentistry and Public Oral Health
Abstract
Objectives: To evaluate the efficacy of toothpaste containing glycyrrhiza and curcuma longa extracts as an adjunct to scaling and root planing (SRP), versus a negative control, in reducing gingivitis and the relative abundance (RA) of periodontal pathogens.
Methods: This was a randomized, double-blinded, placebo-controlled, single-center, three-month clinical trial. Each subject aged 20 to 69 years had ≤2 teeth with a probing depth >4 mm at each quadrant. At baseline, a placebo or anti-bacterial toothpaste was given to each subject. The first clinical examination and gingival crevicular fluid (GCF) sampling were performed just before SRP. After 2, 6, and 10 weeks of SRP, clinical examination and GCF sampling were performed again. The clinical index included the percentage of bleeding on probing (%BOP) and Loe and Silness’s gingival index (GI). The RA of seven species of periodontal pathogens was measured in GCF samples using real-time polymerase chain reaction.
Results: Forty-three subjects (21 and 22 subjects in the control and experimental groups, respectively) were analyzed. In the experimental group, the reduction of gingivitis at 10 weeks was significantly greater than that in the placebo group in terms of GI (p=0.128) and %BOP (p=0.004) scores. The RA of Porphyromonas gingivalis decreased a little more over all follow-up periods in the experimental group than in the placebo group. There was a significantly greater reduction in the RA of Tannerella forsythia at 2 weeks in the experimental group versus placebo (p=0.023).
Conclusions: A toothpaste containing glycyrrhiza and curcuma longa extracts may reduce gingivitis and RA of periodontal pathogens.
키워드
gingivitis; chronic periodontitis; randomized controlled trial; real-time polymerase chain reaction; toothpastes
원문 및 링크아웃 정보
등재저널 정보